Discovery Park Undergraduate Research Internship Program

"Development of Carrier-Free Drug Delivery System for Cancer Therapy"

About the Project

Project Time & Type:
Summer 2015 - DURI
Research area(s):
Cancer; Drug Delivery; Materials Science; Nano
Project Description:
Drug delivery for cancer therapy is far from being satisfactory. A significant portion of potential drug compounds fail to enter the clinic because they cannot be formulated and delivered by existing approaches. Many clinically used formulations are poorly designed, bearing significant adverse effects and limiting treatment efficacy. Over the last few years, nanotechnology has been embraced for developing novel drug delivery systems to combat diseases such as cancer and infection. In our laboratory, we have been developing multicomponent nanocrystals to deliver cytotoxic agents along with bioimaging probes to treat and detect tumors.
Expected Student Contributions:
In this project, the delivery system will be fully tested in vitro and in vivo in order to understand the pharmacokinetic and biodistribution properties and to further improve the formulation design. In particular, the student will be learning and conducting cellular uptake experiment and help graduate students in their animal studies. It is expected that the student will gain a basic understanding of drug delivery for cancer and comprehend the current challenges in cancer therapy. The student will also learn the underlying design principles of our delivery system and, hopefully, provide meaningful suggestions for improvement.
Related Website(s):
http://xtal.ipph.purdue.edu
Desired Qualifications:
GPA > 3.5; major in chemistry, biology, or related field.
Estimated Weekly Hours:
40
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Name:
Li, Tonglei
Deptartment/College:
industrial and physical pharmacy

Student Supervisor

Name:
Wei Gao
Title:
Postdoc

Cooperating Faculty

Name:
Kinam Park
Deptartment/College:
Biomedical Engineering