Discovery Park Undergraduate Research Internship Program

"Electrical-pulse-mediated effective drug delivery for breast cancer"

About the Project

Project Time & Type:
Fall 2015 - DURI
Research area(s):
Biology
Project Description:
Breast cancer is the most common cancer for women worldwide. This is due to the various hormonal changes that occur from puberty to young adult to premenopause and menopause stages. Each year over one million new cases occur and ovr 500,000 women die. US is no exception to this. With six American women diagnosed with breast cancer and one dying every 13 minutes, the need for alternate, safe, affordable and effective treatment cannot be overstated. Affordability is a critical issue as 62% of all foreclosures and bankruptcies in the US are due to medical expenses. Towards this, electrical pulse-mediated chemo drug delivery, known as Electrochemotherapy, is a boon to these patients, especially to those who have inoperable or chemo-resistant or radio-resistant. In this project, various human breast cancer cell lines, including MCF-7 and MBA-MD-231 breast cancer cells will be treated with various cancer drugs and curcumin, the yellow pigment of turmeric, the Indian gold spice using electrical pulses of various voltages and durations. Their efficacy will be characterized using trypan blue viability assay and other assays at various doses.
Expected Student Contributions:
Learn culture work, prepare the samples to do electroporation, pulse them and characterize the viability and other parameters
Related Website(s):
None
Desired Qualifications:
Junior 3.5 and above Interst and willing to learn new techniques and implement, do, th research experiemnts and analyze the results, and present them
Estimated Weekly Hours:
9
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Name:
Sundararajan, Rajeswari
Deptartment/College:
school of engineering technology

Student Supervisor

Name:
Raji Sundararajan
Title:
Professor

Cooperating Faculty

Name:
Ignacio Camarillo
Deptartment/College:
Biological Sciences