Discovery Park Undergraduate Research Internship Program

"Vitamin D and Breast Cancer Prevention"

About the Project

Project Time & Type:
Full-Year 2018 - CPIP
Research area(s):
vitamin D, breast cancer, metabolism
Project Description:
Vitamin D has been proposed to inhibit the progression of breast cancer and our laboratory is focused on understanding the mechanisms of this effect. In breast cancer progression cell energy metabolism is altered, such that cancer cells have higher demand for glucose and glutamine, and increased lipid accumulation to support rapid growth. Our laboratory has shown that vitamin D inhibits glucose, glutamine and lipid metabolism in untransformed 'normal' cells and metastatic cells; from early to late progession of breast cancer. The current project will focus on exploring if the energy metabolism that is egulated by vitamin D plays a role in migration or metastasis of breast cancer cells in specific stages of breast cancer progression.
Expected Student Contributions:
The intern will have an independent project under the direction of a graduate student in the laboratory and will culture, treat and harvest mammalian cells and complete other appropriate analyses such as protein assays, Western blotting and rtPCR.
Related Website(s):
Desired Qualifications:
Previous experience in laboratory procedures and a background in topics related to biology are preferred, but not required.
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Teegarden, Dorothy
Nutrition Science

Student Supervisor

Dorothy Teegarden

Cooperating Faculty

Micheal Wendt
MCMP, Pharmacy