Discovery Park Undergraduate Research Internship Program

"characterization of the mechanical and degradative properties of different crosslinkers on a basement membrane analog"

About the Project

Project Time & Type:
Fall 2014 - DURI
Research area(s):
Biomaterials, Tissue Engineering
Project Description:
The mechanical and biodegradative properties of tissue engineered constructs are a key parameter in the design of restorative tissue scaffolds. Matching the structural characteristics to native tissue is imperative for optimized performance. In this project, the student will assess the impact of different chemical cross linking agents on the mechanical and degradative properties of a base material composed of basement membrane. The results will be used to establish a data set that will ultimately be used to design implantable collagen scaffolds for use in neural and muscle repair and regeneration.
Expected Student Contributions:
Student responsibilities: the student will be responsible for conducting tensile and degradation studies following ASTM guidelines. Specifically, the student will fabricate the necessary collagen blanks, perform tensile testing of these blanks at various designated timepoints and conduct the data analysis on force deformation curves.
Related Website(s):
Desired Qualifications:
materials testing (tensile testing) or mechanical engineering background preferred
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 2 credit hours

Professor in Charge

Li, Jianming
center for paralysis research

Student Supervisor

Jianming Li
Research Asst. Professor

Cooperating Faculty

Richard Borgens