Discovery Park Undergraduate Research Internship Program

"Natural products as anti-cancer stem cell agents to prevent tumor relapse"

About the Project

Project Time & Type:
Summer 2013 - DURI
Research area(s):
Cancer biology
Project Description:
Treatment of many tumors is usually successful at first and most patients initially respond to therapy, but despite the development of potent new regimens, many relapse that becomes drug-resistant. This observation suggests a likely role for the drug-resistant cancer stem cells in tumor relapse. The cancer stem cell hypothesis postulates that only a small sub-population cells can initiate a tumor or cause a relapse, thus developing new therapies that can target these cells will allow us to prevent the differentiation of these cells from non-proliferating rare cells to a tumor generating population. The objective of this study is to test the potential of various plant-derived natural products to eliminate cancer stem cells in multiple myeloma.
Expected Student Contributions:
The intern will be responsible for an independent project (outlined above) and will be closely supervised by the PI and the graduate student supervisor. The intern will conduct all the experiments, and will analyze and present the data at lab meetings and other on-campus and off-campus venues. The PI will assist with experimental design and execution, data analysis, and will guide the intern though the process of making and presenting both posters and talks.
Related Website(s):
http://kirshner.bio.purdue.edu/Lab.html
Desired Qualifications:
Students with 3.2 GPA or higher are welcome to apply. Completion of cell biology courses and labs is recommended, but not required. Some experience with mammalian tissue culture and microscopy is a plus.
Estimated Weekly Hours:
40
Department awards independent research credits for this project?
No

Professor in Charge

Name:
Kirshner, Julia
Deptartment/College:
biological sciences

Student Supervisor

Name:
Mary Zheng
Title:
Graduate student

Cooperating Faculty

Name:
David Colby
Deptartment/College:
MCMP/Pharmacy