Discovery Park Undergraduate Research Internship Program

"Nanomanufacturing of Theranostic Drug Delivery Systems for Cancer Treatment"

About the Project

Project Time & Type:
Spring 2013 - DURI
Research area(s):
drug delivery; cancer therapy; diagnosis
Project Description:
Drug delivery for cancer therapy is far from being satisfactory. A significant portion of potential drug compounds fail to enter the clinic because they cannot be formulated and delivered by the current approaches. Moreover, many existing clinically used formulations are poorly designed, bearing extremely adverse effects and limiting the treatment efficacy. Over the last few years, nanotechnology has been embraced for developing novel drug delivery systems to combat diseases such as cancer and infection. In our laboratory, we have been developing multicomponent nanocrystals to deliver cytotoxic agents along with bioimaging probes to treat and detect tumors. In this project, a new nanomanufacturing technique will be developed and optimized in order to produce large-quantity and high-quality nanocrystals that may be used in clinical trials. In particular, we will produce hybrid nanocrystals that are capable of emitting detectable signals for the use of bioimaging. A background in chemical engineering or chemistry is highly desired.
Expected Student Contributions:
The intern will help the postdoc to test nanocrystals formulated in our lab. In particular, the intern will measure the cellular uptake of the nanocrystals with confocal microscope, and determine how surface properties of the nanocrystals can impact the cellular uptake.
Related Website(s):
Desired Qualifications:
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Li, Tonglei
industrial and physical pharmacy

Student Supervisor

Zhaohui Wang
Postdoctoral Associate

Cooperating Faculty

Kinam Park
Biomedical Engineering