Discovery Park Undergraduate Research Internship Program

"epigenetics, progenitor cells and breast cancer onset"

About the Project

Project Time & Type:
Fall 2012 - DURI
Research area(s):
biology, epigenetics, nutritrion, engineering
Project Description:
The project focuses on the importance of epigenetic modifications in early epithelial tissue alterations that lead to breast cancer development. Notably, the impact of fatty acids that influence breast cancer risk will be assessed on histone modification mechanisms in progenitor/stem and nonstem cells in the mammary epithelium. The work will include the study of non-neoplastic cell lines derived from women at low and high risk levels of developing breast cancer. The measurement of epigenetic changes will include protein quantification and fluorescence microscopy.
Expected Student Contributions:
The student will learn how to design experiments, analyze data, and present results. She/he will be in charge of literature search on the topic of interest, and will perform experiments related to gene expression analysis by RT-PCR, western blotting and microscopy under the supervision of a senior graduate student in the laboratory. As schedule permits, She/he also will be expected to present the work on posters and via slide shows whenever there is an opportunity for such presentation on campus.
Related Website(s):
Desired Qualifications:
previous experience in research training. GPA of at least 3.
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Lelievre, Sophie
basic medical sciences

Student Supervisor

Kim mcDole

Cooperating Faculty

Joseph Irudayaraj