Discovery Park Undergraduate Research Internship Program

"Investigating model for infection-induced gastric cancer"

About the Project

Project Time & Type:
Full-Year 2012 - CPIP
Research area(s):
cancer prevention, infection, gastrointestinal
Project Description:
Recent evidence points to the role of bacterial toxins in the hyper-proliferation of gut stem cells, associated with neoplastic growth. A Drosophila model is being developed to explore the etiology of this aberrant growth process, using chemical agents as well as an bacterial vector (Psuedomonas). Fluorescence confocal microscopy will be used to evaluate changes in cell proliferation in larval and adult Drosophila. If significant hyper-proliferation is confirmed, an antibiotic treatment will be developed to neutralize the effect of the bacterial toxins.
Expected Student Contributions:
culturing of drosophila specimens (Chang lab) culturing and adminstration of bacterial cultures (Wei lab) fluorescence confocal microscopy micro-dissections
Related Website(s):
http://www.chem.purdue.edu/awei/ http://www.bio.purdue.edu/development_disease/directory.php?refID=180
Desired Qualifications:
GPA > 3.4; 2-3 credits undergrad. research during school year.
Estimated Weekly Hours:
10
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Name:
Wei, Alexander
Deptartment/College:
chemistry

Student Supervisor

Name:
Henry Chang
Title:
Associate Professor

Cooperating Faculty

Name:
Henry Chang
Deptartment/College:
Biological Sciences