Discovery Park Undergraduate Research Internship Program

"Plk1 in prostate cancer"

About the Project

Project Time & Type:
Full-Year 2012 - CPIP
Research area(s):
prostate cancer, oxidative stress, cell cycle
Project Description:
We aim to understand how prostate cancer is initiated. It was well-established that oxidative stress is one major reason to initiate prostate cancer in older men, however, the molecular mechanism behind this is not clear. We aim to understand how a critical cell cycle regulator, called Polo-like kinase 1 (Plk1), affects oxidative stress-induced prostate cancer initiation and progression. In particular, we aim to understand the role of Plk1 in epithelial to mesenchymal transition, a critical step in cancer metastasis.
Expected Student Contributions:
The intern will perform the following experiments: plasmid preparation, cell culture, transfection, Western blotting etc. The routine work to finish the project
Related Website(s):
http://www.ag.purdue.edu/biochem/Pages/liu8.aspx
Desired Qualifications:
students with life science major
Estimated Weekly Hours:
10
Department awards independent research credits for this project?
Yes, 2 credit hours

Professor in Charge

Name:
Liu, Xiaoqi
Deptartment/College:
biochemistry

Student Supervisor

Name:
Long Chen
Title:
Graduate student

Cooperating Faculty

Name:
Tim Ratliff
Deptartment/College:
Veterinary medicine