Discovery Park Undergraduate Research Internship Program

"Aldehyde-mediated cell death and tretaments"

About the Project

Project Time & Type:
Fall 2011 - DURI
Research area(s):
Project Description:
Neurodegenerative diseases including Parkinson’s (PD), multiple sclerosis (MS), and others continue to plague an increasing portion of the population without effective treatments available to slow or halt their destruction. However, a possible route for treatment exists in targeting oxidative stress and the toxic aldehydes. Many aldehydes damage proteins, lipids, and DNA. Further, it is both the product and a cause of lipid peroxidation, which results in a vicious cycle of oxidative stress leading to cell death. Therefore, we have indentified aldehydes as effective targets to reduce cell death and offer neuroprotection in both trauma and neurodegenerative diseases. Despite the availability of several existing aldehyde scavengers, new and more effective compounds are needed to enhance the effectiveness of this therapy. This project will involve identifying novel aldehyde scavengers with high effectiveness and low toxicity.
Expected Student Contributions:
The undergraduate student researcher is expected to establish an effective protocol to serve as an initial screen for potential aldehyde scavenging drugs. The project will involve preparing different solutions, keeping a cell-line, and microscopy. The intern will also present their findings in laboratory meetings and potential publications.
Related Website(s):
Desired Qualifications:
A successful applicant should have Sophomore, Junior, or Senior standing in an Biological, Chemical, or Pharmaceutical major with a GPA: 3.5 and above. They must possess a strong work ethic, willingness to learn new techniques, and an interest in both basic and applied research. Familiarity with cell culture is a plus.
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 4 credit hours

Professor in Charge

Shi, Riyi
basic medical sciences

Student Supervisor

Gary Leung
research assistant

Cooperating Faculty

Chris Rochet
School of Pharmacy