Discovery Park Undergraduate Research Internship Program

"New antibacterial wound dressings: mechanism of action and translational studies"

About the Project

Project Time & Type:
Summer 2011 - DURI
Research area(s):
microbiology, biology, veterinary medicine
Project Description:
This is a continuation of the current project dealing with antimicrobial formulations for wound dressings. We have recently developed a new mechanism of bactericidal action that involves low-toxicity, environmentally safe agents. This study will involve bacterial testing of these various antibacterial compounds alone and in combination. Properties of interest include the minimum inhibitory concentrations and potential synergistic action against gram positive and gram negative strains of pathogenic bacteria. These bactericidal parameters will be complemented with careful mechanism of action studies. This project will also involve preliminary in vivo investigations where we will be assessing the overall safety and efficacy of these unique wound dressings in rodent models.
Expected Student Contributions:
The intern will contribute in several ways: First, he/she will be responsible for running multiple antibacterial activity assays with different chemical compounds. This will include actual microbiologic experimentation and data analysis. Secondly, the intern will facilitate animal surgeries and may assist in animal husbandry. Finally, the intern will also be involved with wound bed assessment using optical tools as well as tissue processing/analysis for publication.
Related Website(s):
Desired Qualifications:
3.0+ GPA, preferable junior or senior. Must have some cell biology/microbiology background. Will be working with animals.
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 4 credit hours

Professor in Charge

Li, Jianming
BMS/center for paralysis research

Student Supervisor

Jianming Li
Post-Doctoral Fellow

Cooperating Faculty

Richard Borgens
Biomedical Engineering
Riyi Shi
Biomedical Engineering/BMS