Discovery Park Undergraduate Research Internship Program

"Role of Cdk5 kinase in Alzheimer's Disease"

About the Project

Project Time & Type:
Fall 2010 - DURI
Research area(s):
Chemical Biology and Biochemistry
Project Description:
Alzheimer’s Disease (AD) is a debilitating neurological disorder affecting over 5 million Americans. AD is characterized by three major hallmarks: beta-amyloid plaques, neurofibrillary tangles (NFTs) with profound death in specific areas of the brain. The molecular mechanism leading to extensive neurodegeneration remains to be fully elucidated. Multiple studies have revealed a critical role of Cyclin Dependent Kinase-5 (Cdk5) in triggering various neurotoxic cascades in AD. Cdk5 deregulation contributes to all three hallmarks of AD: neurotoxic amyloid beta and NFT formation and extensive neurodegeneration. Our goal is to dissect the role of Cdk5 kinase in neuronal death pathways.
Expected Student Contributions:
She will be doing molecular cloning of Cdk5 substrates, protein expression and purification and kinase assays.
Related Website(s):
http://www.chem.purdue.edu/shah/
Desired Qualifications:
None
Estimated Weekly Hours:
9
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Name:
Shah, Kavita
Deptartment/College:
chemistry

Student Supervisor

Name:
Kuei-Hua Chang
Title:
Graduate Student

Cooperating Faculty

Name:
Kuei-Hua Chang
Deptartment/College:
N/A
Name:
N/A
Deptartment/College:
N/A