Discovery Park Undergraduate Research Internship Program

"Development of techniques to measure DNA repair in phenotypically normal and cancer cells"

About the Project

Project Time & Type:
Fall 2010 - DURI
Research area(s):
biology, engineering, nanotechnology
Project Description:
This project aims at better understanding how the organization of the cell nucleus influences the repair of DNA strand breaks. Specifically the student will apply single-molecule techniques to examine the interaction between nuclear architectural and DNA repair proteins, and to measure DNA damage-induced chromatin modifications in 3D cell culture models of normal and cancerous breast tissues.
Expected Student Contributions:
The intern will participate in the design and execution of the experiments using nanotechnology-, cell biology- and molecular biology-based techniques. The student will also learn to troubleshoot experiments and present results.
Related Website(s):
None
Desired Qualifications:
GAP at least 3.5
Estimated Weekly Hours:
9
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Name:
Lelievre, Sophie
Deptartment/College:
basic medical sciences/veterinary medicine

Student Supervisor

Name:
Sophie Lelievre
Title:
Associate Professor of Basic Medical Sciences

Cooperating Faculty

Name:
Joseph Irudayaraj
Deptartment/College:
ABE/Enginering