Discovery Park Undergraduate Research Internship Program

"Cancer Stem Cells In Multiple Myeloma"

About the Project

Project Time & Type:
Fall 2010 - DURI
Research area(s):
Cancer Biology
Project Description:
Multiple myeloma (MM) is an incurable bone marrow (BM) malignancy of B cell lineage characterized by monoclonal plasma cells (PCs) in the BM and accounts for 19% of deaths from blood cancers. Most patients initially respond to therapy, but despite the development of potent new regimens, nearly all relapse and become refractory to treatment; thus the median survival rate remains 3-5 years. These observations indicate that the MM cancer stem cells (MM-CSCs) escape current modes of therapy. The cancer stem cell hypothesis postulates that only a small sub-population cells can initiate a tumor or cause a relapse, thus identifying these cells will allow us to design new therapies to eliminate these cancer initiating cells. The objective of this study is to determine the identity of the MM-CSC.
Expected Student Contributions:
The intern will be responsible for an independent project (outlined above) and will be closely mentored by the PI. The intern will conduct all the experiments and will analyze and present the data at lab meetings and other on-campus and off-campus venues. The PI will assist with experimental design and execution, data analysis, and will guide the intern though the process of making and presenting both posters and talks.
Related Website(s):
Desired Qualifications:
Students with 3.3 GPA or higher at any level are welcome to apply. Completion of general and organic chemistry along with cell biology courses and labs is recommended, but not required. Some experience with mammalian tissue culture is a plus, but not required.
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Kirshner, Julia
biological sciences

Student Supervisor

Ellen Gunn
Graduate Student

Cooperating Faculty

David Colby
Medicinal Chemistry and Molecular Pharmacology