Discovery Park Undergraduate Research Internship Program

"Translation of High Throughput Screening to Pharmacological Impact"

About the Project

Project Time & Type:
Fall 2010 - DURI
Research area(s):
bioengineering, cell biology, statistical analysis
Project Description:
This project is focused on translating functional biological assays into very high throughput analytical systems. Data are collected on flow cytometers in multiparameter format and stored. The assays themselves involve several other staff and students. The fundamental problem that this student would focus on would be the methods for understanding how to manipulate the data to understand the relationships between different drugs and the types of responses they elicit in cell culture systems. This would involved developing protocols that allow us to understand the variety of cellular responses to drug induced inhibition of function. Depending on the student's background, this project could involve some participation in assay development or be focused on the analytical component.
Expected Student Contributions:
The student would work with very large data sets and work with software tools to perform multiparameter analysis. Some computation would be required and the student would need to learn some basic information about how different drugs modulate specific cellular responses.
Related Website(s):
http://www.cyto.purdue.edu
Desired Qualifications:
student with engineering background with interest in cell biology, software tools, modeling and be interested in the engineering-biology interface.
Estimated Weekly Hours:
12
Department awards independent research credits for this project?
Yes, 4 credit hours

Professor in Charge

Name:
Robinson, Joseph
Deptartment/College:
basic medical sciences

Student Supervisor

Name:
J. Paul Robinson
Title:
Professor

Cooperating Faculty

Name:
V. Jo Davisson
Deptartment/College:
College of Pharmacy