Discovery Park Undergraduate Research Internship Program

"CPIP: Characterization of Protein-Protein Interactions in the FGF family"

About the Project

Project Time & Type:
Full-Year 2010 - CPIP
Research area(s):
biochemistry, proteomics
Project Description:
The Fibroblast Growth Factor (FGF) family is directly implicated in a strikingly diverse set of biological activities in vivo that include induction of angiogenesis, induction of limb outgrowth, maintenance of limb patterning and development of bone. FGFs have been shown to be expressed at increased levels in tumors and act as paracrine and/or autocrine growth factors for cancer cells. In addition, deregulation of FGF signaling has been shown to lead to cancer progression. The members of the FGF family include high affinity tyrosine kinase receptors, an intracellular cysteine-rich receptor, low affinity heparin sulfate proteoglycan receptors and growth factor ligands. Many of the members within the FGF family are alternatively spliced and expressed as alternative protein isoforms. Evidence suggests that cancer cell growth and tumor progression can be controlled by specifically altering the properties of FGF signaling pathways. Our goal is to develop new technological methods for characterizing the FGF cellular interactome and identify potential inhibitors of FGF signaling that could have therapeutic potential.
Expected Student Contributions:
The intern will help validate the new technology and collect research data within the experimental system to further characterize the FGF interactome within neural stem cells.
Related Website(s):
Desired Qualifications:
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Clase, Kari
industrial technology

Student Supervisor

Kari Clase
Assistant Professor

Cooperating Faculty

Jenna Rickus