Discovery Park Undergraduate Research Internship Program

"CPIP: Novel nanotechnologies for studying cancer signaling"

About the Project

Project Time & Type:
Full-Year 2010 - CPIP
Research area(s):
chemical biology, cancer prevention, kinase signaling, nanotechnology
Project Description:
This project is aimed at developing new ways to detect kinase activity in cells. Kinases are important to the cell cycle and apoptosis, and when they go haywire it often contributes to turning normal cells into cancerous cells. Many important modern chemotherapies are targeted at stopping these cancer-related kinases, but there are very few ways that the kinase enzyme activities can be observed in live cells--so from the lab to the clinic, it can be difficult to know just what is going on with these enzymes and whether the inhibitor drugs are working or not. We will test novel nanotechnology ideas for methods to solve these problems.
Expected Student Contributions:
Undergraduates working on the project will learn how to make nanomaterials that have peptide substrates for the kinase enzymes attached. They will participate in testing these nanomaterials with kinases and inhibitors, and using different instruments for detecting the phosphorylation.
Related Website(s):
Desired Qualifications:
minimum GPA of 3.2 is desired, experience in chemistry (especially peptide and nanoparicle synthesis) and biochemistry (especially kinase assays) is desired.
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 2 credit hours

Professor in Charge

Parker, Laurie
medicinal chem/molecular pharmacology

Student Supervisor

Andrew Lipchik
Graduate Research Assistant

Cooperating Faculty

Joseph Irudayaraj
Agricultural and Bioengineering
Dorothy Teegarden
Foods and Nutrition