Discovery Park Undergraduate Research Internship Program

"CPIP: Role of CDS1 gene in breast cancer prevention"

About the Project

Project Time & Type:
Full-Year 2010 - CPIP
Research area(s):
breast cancer, tissue polarity, gene expression
Project Description:
CDS1 is a gene that has been involved in lipid signaling pathways. We have found that this gene responds to the loss of apical polarity, a feature thought to be necessary for the initiation of breast cancer. Thus, CDS1 might be an important target to develop breast cancer prevention strategies. The first aim of the project is to decipher the changes in CDS1 expression that accompany breast cancer progression using archival tissue sections and a cell culture model of breast cancer initiation and progression in order to identify which steps might be critically influenced by CDS1. The second aim of the project is to investigate how CDS1 controls tumor development by manipulating CDS1 expression in models of breast acinar differentiation and tumors of different grades.
Expected Student Contributions:
The intern will be involved in all steps of the project and will work in collaboration with a graduate student whose project deals with the mechanisms of apical polarity control. She/he will participate in the design and interpretation of experiments, will be in charge of specific experiments and will also study the literature on CDS1 and early stages of breast cancer development. The student will learn to present the research project for poster and oral presentations and will be involved in the writing of manuscripts related to his/her own part of the project.
Related Website(s):
Desired Qualifications:
those of the CPIP
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Lelievre, Sophie
basic medical sciences

Student Supervisor

Sophie Lelievre
Associate Professor of basic medical sciences

Cooperating Faculty

Sunil Badve (pathologist)
IU cancer Center (IUPUI)