Discovery Park Undergraduate Research Internship Program

"DURI: In vivo whole brain vascular network imaging "

About the Project

Project Time & Type:
Fall 2017 - DURI
Research area(s):
neurophotonics, bioimaging, optical science and engineering, image processing
Project Description:
In this project, we will develop a novel and powerful imaging technology, which allows us to quantify the blood flow speed, vessel dilation, and blood oxygen level across the entire mammalian brain. To provide a flavor of our research, we list a few of our recent publications here. 1. Park, Jung-Hoon, Lingjie Kong, Yifeng Zhou, and Meng Cui. "Large-field-of-view imaging by multi-pupil adaptive optics." Nature Methods 14, no. 6 (2017): 581-583. 2. Kong, Lingjie, Jianyong Tang, Justin P. Little, Yang Yu, Tim Lämmermann, Charles P. Lin, Ronald N. Germain, and Meng Cui. "Continuous volumetric imaging via an optical phase-locked ultrasound lens." Nature methods 12, no. 8 (2015): 759-762. Highlighted by Nature Photonics 9, 553 (2015) 3. Park, Jung-Hoon, Wei Sun, and Meng Cui. "High-resolution in vivo imaging of mouse brain through the intact skull." Proceedings of the National Academy of Sciences 112, no. 30 (2015): 9236-9241. 4. Tang, Jianyong, Ronald N. Germain, and Meng Cui. "Superpenetration optical microscopy by iterative multiphoton adaptive compensation technique." Proceedings of the National Academy of Sciences 109, no. 22 (2012): 8434-8439. Highlighted by Nature Methods 9, 642 (2012) 5. Si, Ke, Reto Fiolka, and Meng Cui. "Fluorescence imaging beyond the ballistic regime by ultrasound-pulse-guided digital phase conjugation." Nature photonics 6.10 (2012): 657-661.
Expected Student Contributions:
The student will directly work with the PI to develop the technology and apply the technology to answer key biology questions.
Related Website(s):
Desired Qualifications:
Knowledge on optics and lasers are preferred but not required.
Estimated Weekly Hours:
Department awards independent research credits for this project?

Professor in Charge

Cui, Meng

Student Supervisor

Meng Cui
Assistant professor

Cooperating Faculty

Yifeng Zhou