Discovery Park Undergraduate Research Internship Program

"Tissue stiffness-cell nucleus relationship in normal and cancerous cell behaviors"

About the Project

Project Time & Type:
Fall 2016 - DURI
Research area(s):
Biology, Engineering Pathology,
Project Description:
The project will include the study of nuclear morphology and pathways involved in conveying physical strains to the cell nucleus under conditions associated with breast cancer onset and sensitivity to treatment. The models used are based on 3D cell culture, notably organs-on-a-chip.
Expected Student Contributions:
The intern will contribute to the project by performing cell biology experiments and analysis of the nuclear organization using programs such as ImageJ. The intern will also review the literature on the topics of the project, and interact with engineering students who are also working on the project. The intern will present his/her results at weekly meetings and during poster presentations, and will work in close collaboration with graduate and/or postdoctoral trainees in the laboratory.
Related Website(s):
Desired Qualifications:
Those required by DURI
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Lelievre, Sophie
basic medical sciences

Student Supervisor

Sophie Lelievre

Cooperating Faculty

Babak ZIaie