Discovery Park Undergraduate Research Internship Program

"3D cell culture models to study oxidative stress in cancer progression"

About the Project

Project Time & Type:
Fall 2016 - DURI
Research area(s):
Biology and Engineering
Project Description:
The project will include testing 3D cell culture models with breast cancer cells for which gradients of oxidative stress are generated. Experiments will encompass assessing toxicity, cellular responses to oxidative stress, and changes in nuclear organization and gene expression. The models will also be tested with compounds that are potential protectors or inducers of oxidative stress.
Expected Student Contributions:
The intern will contribute to the project by performing immunostaining and western blotting experiments as well as analysis of results, reviewing the literature on the topics of the project, and interacting with engineering students who are also working on the project. The intern will present his/her results at weekly meetings and during poster presentations, and will work in close collaboration with graduate and/or postdoctoral trainees in the laboratory.
Related Website(s):
Desired Qualifications:
Those requested by DURI
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Lelievre, Sophie
basic medical sciences

Student Supervisor

Sophie Lelievre

Cooperating Faculty

Babk Ziaie