Discovery Park Undergraduate Research Internship Program

"Disease on chip for drug screening"

About the Project

Project Time & Type:
Spring 2016 - DURI
Research area(s):
biology and engineering
Project Description:
The disease-on-chip (DOC) system was designed to mimic different stages of the development of breast cancer within the terminal duct of the mammary gland. In this system, tumor nodules grow in contact with the non-neoplastic epithelium that lines the duct and within a semi-circular geometry (ductal constraint). The purpose of the proposal is to assess the possibility to better assess drug sensitivity of specific types of breast cancers using different forms of engineered DOC. The efficacy of anticancer drugs depending on the tumor environment will be tested by comparing different settings used for drug screening. An important aspect will be to validate the physiological relevance of the DOC by comparing the architecture of the tumor nodules generated in that system to real tumors of the same type.
Expected Student Contributions:
The intern will contribute to the project by analyzing the results from experiments related to drug treatments (e.g., scoring of cell death and proliferation) and assessment of intracellular architecture (e.g., nuclear circularity). Most of the experiments will be microscopy-based.
Related Website(s):
Desired Qualifications:
interest and some knowledge in pharmacology
Estimated Weekly Hours:
Department awards independent research credits for this project?
Yes, 3 credit hours

Professor in Charge

Lelievre, Sophie
basic medical sciences

Student Supervisor

Sophie Lelievre

Cooperating Faculty

Babak Ziaie